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Metabolism Alprazolam is thoroughly metabolized in human beings, primarily by cytochrome P450 3A4 (CYP3A4), to 2 important active metabolites while in the plasma: four-hydroxyalprazolam and α-hydroxyalprazolam. The plasma circulation amounts of the two Energetic metabolites are less than 4% with the dad or mum. The reported relative potencies in b